Jan 31 2008
Gymnema Sylvestre Part 2 - Effects of GS4
As we have already seen, GS4, an extract of Gymnema Sylvestre, has been shown to lower blood glucose levels. The truth is, however, that it does a lot more than that.
Effects of GS4 on glucose stability was studied in rats. In the first set of experiments, the acute effect of GS4 was examined in both non-diabetic and streptozocin induced mildly diabetic rats. Administration of 1 g of GS4 to 18-hr fasted non-diabetic rats significantly deteriorated the serum glucose response to oral administration of 1 g/kg glucose. The IRI response in GS4-administered rats was lower, but not significantly, than that in non-administered rats. In mildly diabetic rats, a 60 min increment in serum glucose concentrations was significantly reduced by GS4 administration.
In the second set of experiments, the chronic effect of GS4 was examined in mildly diabetic rats. Two weeks after the induction of diabetes, the rats were divided into two groups that had similar impairment of glucose tolerance. The rats were fed for 32-35 days with either a controlled diet or a diet supplemented with GS4. After 4 weeks, GS4 showed a tendency to reduce the serum glucose concentrations in the fed state and to improve the glucose tolerance. Gain in body weight, food intake, pancreas weight and the pancreatic contents of IRI, protein, amylase and trypsinogen were unaffected in the GS4-treated group compared with the controlled.
The effectiveness of GS4 in controlling hyperglycemia was also investigated in 22 Type 2 diabetic patients on conventional oral anti-hyperglycemic agents. 400 mg of GS4 per day was administered for 18-20 months as an addition to the conventional oral drugs. During GS4 supplementation, the patients showed a significant reduction in blood glucose, glycosylated hemoglobin and glycosylated plasma proteins, and conventional drug dosage could thus be decreased. Five of the 22 diabetic patients were able to discontinue their conventional drug and to stabilize their blood glucose with GS4 alone.
Evidence thus far has shown the effectiveness of GS4 in controlling blood glucose and hyperglycemia. With the growing availability of Gymnema Sylvestre, diabetics and others consumers will soon be able to take advantage of this effective supplement.